The Green Futures of Tycho

Dr. William W. Sleator, father of the author

Dr. William W. Sleator

William Sleator

Professor Emeritus
Physiology, Biophysics
PhD, 1946, University of Michigan
To Contact:
453A Burrill Hall

cellular processes in muscle

The work in my laboratory is directed toward elucidating some of the
fundamental cellular processes in muscle. One of the objectives is
analysis of the excitation contraction coupling mechanism in heart muscle.
The methods employed include measurement of transmembrane action
potentials by means of intracellular microelectrodes, measurement of the
influx and efflux of calcium and other ions using radioactive tracer
techniques and ion-selective electrodes, and ultrastructural studies by
electron microscopy. Recent experiments explored the effects of patterns
of stimulation, effects of tetrodotoxin and epinephrine on action
potential parameters such as maximum depolarization rate, and used the
resulting changes in contraction strength to test certain hypotheses about
the activation process. Another project employed calcium ion-selective
microelectrodes to record changes in Ca++ in extracellular space of
cardiac muscle during various patterns of activity.

Selected Publications

Little, G.R. & W.W. Sleator. 1969. Calcium exchange and contraction
strength of guinea pig atrium in normal and hypertonic media. J. Gen.
Phys. 54:494-511. Frank, M. & W.W. Sleator. 1975. Effect of ryanodine on
myocardial calcium. Archiv. Pharmakologie 290:35-47.

Robinson, R.B. & W.W. Sleator. 1977. Effects of calcium and catecholamines
on the guinea pig atrial action potential plateau. Am. J. Physiol.

Suh, C.K. & W.W. Sleator. 1982. Measurements of extracellular calcium ion
in guinea pig atria during activity. Biophys. J. 37:122.
Information courtesy of UIUC Biophysics

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